Advances in Breast Cancer Management, Second Edition by Boris Pasche M.D., PhD, F.A.C.P (auth.), William J.

By Boris Pasche M.D., PhD, F.A.C.P (auth.), William J. Gradishar M.D., William C. Wood M.D. (eds.)

During the final 5 years major growth has been made in our realizing of the biology of breast melanoma. because of linking observations made within the laboratory to new remedy options, the end result of sufferers with either early and overdue degree affliction has persevered to improve.

Advances in Breast melanoma administration, moment Edition will spotlight some of the vital advances that experience reworked our realizing of the biology and therapeutics of breast melanoma.

Series Editor's comments:

"Dramatic advances were witnessed in our wisdom and therapy of breast melanoma during the last decade. this article covers a multidisciplinary spectrum of issues that experience nice relevance for sufferer care. distinctive figures within the box offer updates on key parts of curiosity to clinicians and investigators learning this disease."

Steven T. Rosen, M.D.

Series Editor

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Extra resources for Advances in Breast Cancer Management, Second Edition

Sample text

20 Advances in Breast Cancer Management lower probability of nodal involvement compared to locally advanced breast cancer and committing such a patient to an axillary lymph node dissection because of concerns about feasibility and accuracy in a neoadjuvant setting is to confer a higher risk of the morbidities associated with axillary lymph node dissection. Additionally, larger randomized trials have demonstrated neoadjuvant chemotherapy can sterilize the axilla in 30-40% of patients with known axillary disease48.

59. Julian T. , Dusi, N. Wolmark. 2003. Sentinel node biopsy after neoadjuvant chemotherapy for breast cancer. Am J Surg, 184: 315-17. 60. Miller A. ,V. E. , 2002. Analysis of sentinel lymph node mapping with immediate pathologic review in patients receiving preoperative chemotherapy for breast carcinoma. Ann Surg Oncol, 9(3): 243-47. 61. Balch G. , S. K. Mithani, K. R. , 2003. Lymphatic mapping and sentinel lymphadenectomy after preoperative therapy for stage II and III breast cancer. Ann Surg Oncol, 10(6): 616-21.

The authors noted preoperative lymphoscintigrams showed 7 cases of aberrant lymphatic drainage resulting in operative exploration of non-traditional basins. In 9 of the 11 cases, non-sentinel nodes were obtained and, in all instances, the SLN accurately predicted the involved lymphatic basin. They conclude SLNB is feasible and accurate in the setting of 24 Advances in Breast Cancer Management reoperative axillary surgery but caution imaging of the contralateral axilla as well as other lymphatic basins may be needed preoperatively if the ipsilateral axilla is not the primary drainage basin75.

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