Apoptosis, Cell Signaling, and Human Diseases: Molecular by Rakesh Srivastava

By Rakesh Srivastava

Apoptosis, mobile Signaling, and Human ailments: Molecular Mechanisms, Volumes 1 and a couple of, current a concise synthesis of modern advancements within the realizing of either cellphone survival and apoptotic pathways. specific cognizance is given to apoptosis in human illnesses, corresponding to diversified varieties of melanoma. those entire volumes combine the main cutting edge and present findings. The members are on the leading edge of clinical discovery.

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Extra info for Apoptosis, Cell Signaling, and Human Diseases: Molecular Mechanisms, Volume 2

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113. Halgren RG, Traynor AE, Pillay S, et al. 8Cl-cAMP cytotoxicity in both steroid sensitive and insensitive multiple myeloma cell lines is mediated by 8Cl-adenosine. Blood 1998; 92:2893–2898. 114. Tagliaferri P, Katsaros D, Clair T, et al. Synergistic inhibition of growth of breast and colon human cancer cell lines by site-selective cyclic AMP analogues. Cancer Res 1988;48: 1642–1650. 115. Koontz JW, Wicks WD. Cytotoxic effects of two novel 8-substituted cyclic nucleotide derivaties in cultured rat hepatoma cells.

149. Tortora G, Ciardiello F. Targeting of epidermal growth factor receptor and protein kinase A: molecular basis and therapeutic applications. Ann Oncol 2000;11:777–783. 150. Yang WL, Iacono L, Tang WM, Chin KV. Novel function of the regulatory subunit of protein kinase A: regulation of cytochrome c oxidase activity and cytochrome c release. Biochemistry 1998;37:14,175–14,180 151. Srivastava RK, Srivastava AR, Park YG, Agrawal S, Cho-Chung YS. Antisense depletion of RIalpha subunit of protein kinase A induces apoptosis and growth arrest in human breast cancer cells.

Thus, the diversity and complexity of the cAMP signaling are highly dependent on different stages of normal cellular development and differentiation, and such signaling is disrupted in an abnormal physiology such as cancer. We believe that the large amount 01_Cho_Chung 12/4/06 1:43 PM Page 21 Protein Kinase A in Human Cancer 21 of experimental evidence now accumulated strongly supports the idea that PKA is a valuable target for cancer treatment and diagnosis. References 1. Sutherland EW, Rall TW.

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